SECRETOGLOBIN 3A2 SUPPRESSES BLEOMYCIN-INDUCED PULMONARY FIBROSIS BY TGFbeta SIGNALING DOWN-REGULATION
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چکیده
Reiko Kurotani, Satoshi Okumura, Tsutomu Matsubara, Utako Yokoyama, John R. Buckley, Takeshi Tomita, Kyohei Kezuka, Tomokazu Nagano, Dominic Esposito, Troy E. Taylor, William K. Gillette, Yoshihiro Ishikawa, Hiroyuki Abe, Jerrold M. Ward, and Shioko Kimura Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA Cardiovascular Research Institute, Yokohama City University, Yokohama, Kanagawa, Japan 236-0004 Biochemical Engineering, Faculty of Engineering, Yamagata University, Yonezawa, Yamagata, Japan 992-8510 Protein Expression Laboratory, Advanced Technology Program, SAIC-Frederick, Inc. National Cancer Institute, Frederick, MD 21701, USA Cardiovascular Research Institute, Department of Cell Biology & Molecular Medicine and Medicine (Cardiology), New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA Global VetPathology, Montgomery Village, MD 20866, USA; Running title: SCGB3A2 suppresses bleomycin-induced lung fibrosis Address all correspondence to: Shioko Kimura, PhD, Bldg. 37, Rm. 3106, NIH, Bethesda, MD 20892. Tel: 301-496-0958, Fax: 301-496-8419, E-mail: [email protected]
منابع مشابه
Author's response to reviews Title:Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice Authors:
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Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice
BACKGROUND Secretoglobin (SCGB) 3A2, a cytokine-like secretory protein of small molecular weight, is predominantly expressed in airway epithelial cells. While SCGB3A2 is known to have anti-inflammatory, growth factor, and anti-fibrotic activities, whether SCGB3A2 has any other roles, particularly in lung homeostasis and disease has not been demonstrated in vivo. The aim of this study was to add...
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OBJECTIVE Secretoglobin (SCGB) 3A2 is a novel lung-enriched cytokine, previously shown to exhibit anti-inflammatory, growth factor, and anti-fibrotic activities. The latter activity was demonstrated using exogenously-administered recombinant SCGB3A2 in the bleomycin (BLM)-induced pulmonary fibrosis model. Whether SCGB3A2 exhibits anti-fibrotic activity in vivo is not known. METHODS Mice null ...
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